Dr. Singal is a professor of medicine at the University of Louisville School of Medicine, Director of clinical trials program in liver diseases, transplant hepatologist at the Jewish Hospital and Trager Transplant Center in Louisville KY. In addition, he is a research scientist at the Robley Rex VA Medical Center in Louisville, KY, USA.

With clinical and translational research interests in alcoholic and non-alcoholic fatty liver diseases, renal injury in cirrhosis, and porphyria, Dr. Singal's research has been funded by the American College of Gastroenterology, National Institute of Health, and pharmaceutical industry. He has over 350 original peer-reviewed articles in national/international journals and book chapters. In 2024, Dr. Singal was recruited to the top 2% of world scientists database created and maintained by Elsevier in collaboration with Stanford University.

Dr. Singal's editorial activities include Editorial board (Hepatology, Liver Transplantation, CGH, JHEP Reports, Seminars Liver Disease) and Associate Editor (Clinical Translational Gastroenterology, Current Hepatology Reports, Digestive Liver Disease, Journal of Clinical Translational Hepatology, and Journal of Clinical and Experimental Hepatology).

Apart from reviewing research grants for the AGA and AASLD, Dr. Singal is on the study section for the NIH. He is a lead author on ACG guidelines for alcoholic liver disease and co-authored guidelines on vascular disorders of the liver and nutritional management of patients with cirrhosis. He has chaired the special interest group on alcohol-related liver disease (2020-2021) of the AASLD and is Chair of the Liver Biliary section of the AGA Council.